effect of curcumin on the hypothalamus levels of the potent inhibitory neurotransmitter ,gamma aminobutyric acid

نویسندگان

shokoufe nikpour moghaddam department of biochemistry, school of biology, islamic azad university of falavarjan

durdi qujeq department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, iran

ali asghar rastegari efahani department of biophysics, school of biology, islamic azad university of falavarjan

shaghayeq nikpour moghaddam department of microbiology, school of biology, islamic azad university of tonekabon

چکیده

background: there are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. according to several studies, elevated serum levels of gamma-amino butyric acid (gaba), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. the purpose of this research was to estimate the effects of curcumin on gaba’s level in rat's hypothalamus. materials and methods: we used a standard animal model of rats (n=18) with mean weight 190-210 g, to determine the effects of administration of curcumin at the end of the experimental period, one week, two weeks, four weeks and eight weeks ,at doses of 250 mg/kg and 625 mg/kg on gaba level in hypothalamus. on the day of experiment, hypothalamus was extracted and homogenized through a 10 -µm filter, rinsed with pbs, re-filtered, and centrifuged at 1200 rpm for 15 min. then rat hypothalamus was weighed, and homogenized (10% w/v) in 0.1 m pbs with poltroon homogenizer at ph 7.4. homogenates were used immediately for determination of gaba level. quantifications of gaba in all samples were performed by enzymatic method. results: our results indicate that curcumin has a potential to increase gaba content in the rats' hypothalamus. these results suggest that curcumin holds promise as a natural agent to control or decrease the signs of lack of gaba level. conclusion: curcumin may be used clinically as a neuro-protective drug for treatment of patients suffering from neuron damage.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Curcumin on the Hypothalamus Levels of the Potent Inhibitory Neurotransmitter ,Gamma aminobutyric acid

Background: There are some reports in the literature showing that hypothalamus synthesizes and secretes amino acid neurotransmitters. According to several studies, elevated serum levels of gamma-amino butyric acid (GABA), a potent inhibitory neurotransmitter, have recently been implicated in the pathogenesis of neural diseases. The purpose of this research was to estimate the effects of curcumi...

متن کامل

the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)

cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...

: the effect of sericin levels (silk glue protein) on rate of in vitro maturation, fertilization and culture of sheep oocytes

هدف از آزمایش اول بررسی اثر سطوح مختلف سریسین [0 (control), 0.1, 0.5, 1.0, 2.5 %] افزوده شده به محیط , ivm بر cumulus cell expansion، بلوغ هسته و توسعه متوالی جنین، در گوسفندان نژاد سنجابی در فصل تولید مثلی می باشد. از سرگیری میوز به وسیله خارج شدن اولین پولار بادی اندازه گیری و هم چنین درصد رسیدن جنین های دو سلولی به مرحله کلیواژ و بلاستوسیت نیز به عنوان نشانه ای از میزان شایستگی توسعه اولیه ج...

the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests

در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است

15 صفحه اول

the effect of traffic density on the accident externality from driving the case study of tehran

در این پژوهش به بررسی اثر افزایش ترافیک بر روی تعداد تصادفات پرداخته شده است. به این منظور 30 تقاطع در شهر تهران بطور تصادفی انتخاب گردید و تعداد تصادفات ماهیانه در این تقاطعات در طول سالهای 89-90 از سازمان کنترل ترافیک شهر تهران استخراج گردید و با استفاده از مدل داده های تابلویی و نرم افزار eviews مدل خطی و درجه دوم تخمین زده شد و در نهایت این نتیجه حاصل شد که تقاطعات پر ترافیک تر تعداد تصادفا...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
research in molecular medicine

جلد ۳، شماره ۱، صفحات ۲۲-۲۵

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023